Spin–spin interactions, coupling constant ‘J’ and the spin systems involving two, three and four nuclei, first and second order spectra, geminal, vicinal and long range coupling, dynamic exchange of proton, simplification of complex spectra, double resonance, shift reagents. Unit 3 Nuclear Magnetic resonance: Nuclear Magnetic Resonance, Larmour frequency, chemical shift, factors influencing chemical shift, chemical shift values and correlation for protons bonded to carbon and hetero nuclei. Analysis of mass spectra GCMS and LCMS techniques. Unit 2 Mass spectrometry: Introduction, factors affecting fragmentation, Double McLafferty rearrangement, retro Diels-Alder fragmentation, ortho effect, fragmentation pattern of hydrocarbons (Cyclic), ethers, thioethers, halides, alcohols, phenols, aldehydes, ketones, carboxylic acids, esters, amides, nitro compounds, nitriles etc. Optical rotatory dispersion and circular dichroism. UV-Visible spectroscopy: Electronic excitations, UV absorption by dienes, carbonyl, conjugated and extended conjugated and unsaturated alkenes and carbonyl compounds, aromatic systems, polyynes, biphenyls, Woodward–Fieser rules for conjugated dienes and enones. Kalsi.ĬHE2321COC (3 Credits) Organic Spectroscopy Unit 1 Infrared Spectroscopy: Introduction, characteristic vibrational frequencies for alkanes, alkenes, alkynes, aromatics, alcohols, ethers, phenols, amines and nitro compounds, carbonyl compounds, aldehydes, ketones, esters, amides, acids, anhydride, lactones, lactams and conjugated carbonyl compounds, Effect of hydrogen bonding, ring size and solvent. Stereochemistry of Organic compounds IInd Edition, D. Stereochemistry of Carbon compounds, E.I. Organic Chemistry J Clayden, N Greeves, S Warren, P Wothers, O U P, 2000.
Organic Synthesis, The Disconnection Approach, S. Carruthers, Cambridge University Press, 1986. Some Modern Methods of Organic Synthesis, W. Organic Synthesis Workbook II C Bittner, A.S Busemann, U Griesbach, F. Classics in Total Synthesis II: More Targets, Strategies, Methods K.C. Compendium of Organic Synthetic Methods, Vol. Wills, Oxford Science Publications, 1994. Designing Organic Syntheses : A Programmed Introduction to the Synthon Approach S. Unit 3 Stereochemistry: Homotopic and heterotopic atoms, prochiral systems chirality, molecules with more than one chiral centre, threo and erythro isomers, optical purity, optical activity in absence of chiral carbon, helical molecules, admantoids, catenanes, Conformational analysis of fused bicyclic, tricyclic and bridged ring systems, effect of conformations on reactivity in acyclic and cyclic compounds, Cram’s and Prelog’s rules, stereospecific and stereoselective reactions. Michael addition, Wittig reaction, Mannich reaction, Stork enamine synthesis, Baylis-Hillman reaction, applications of organometallics: use of Grignard reagent, organo-lithium and –copper-lithium complexes. principles and applications of protective groups in protection of hydroxyl, amino, carbonyl and carboxyl groups, synthetic strategies for cyclic compounds, retrosynthesis and synthetic approaches to some complex molecules such as camphor, longifoline, prostaglandins etc Unit 2 Carbon-carbon bond forming reactions: Knovenagel condensation, Darzon condensation. Organic Chemistry M Sc Semester 3 CHE2320COC (3 Credits) Organic Synthesis &Stereochemistry Unit 1 Organic synthesis: Reterosynthsis, synthons and synthetic equivalents, functional group interconversion, Synthesis of amines, regiospecific, chemospecific and stereospecific reactions, umpolung methods.
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